Download E-books The Cancer Chronicles: Unlocking Medicine's Deepest Mystery PDF

By George Johnson

A New York Times amazing booklet of 2013

When the girl he enjoyed was once clinically determined with a metastatic melanoma, George Johnson got down to study every little thing he may perhaps concerning the disorder and the folks who spend their careers attempting to comprehend and to struggle it. What he came upon is a revolution lower than way—an explosion of latest rules approximately what melanoma particularly is and the place it comes from.

Deftly excavating and illuminating a long time of research and research, rooted in each self-discipline from evolutionary biology to video game conception and physics, Johnson explores what we know—and what we nonetheless don't—about melanoma, and why a therapy is still the sort of slippery target. all through his pursuit, Johnson clarifies the human adventure of melanoma with grace, bearing witness to the punishing gauntlet of consultations, surgical procedures, certain treatments, and different remedies. via Johnson’s radiant prose and authoritative point of view on technological know-how, he's taking us on an event during the historical past and up to date advances in melanoma examine that would problem every little thing you notion you knew concerning the disease.

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Nlm. nih. gov/pubmed/6290897] 23. a few mutations are much more wrenching: the easiest recognized instance is the Philadelphia chromosome, that's taken with persistent myeloid leukemia. For the unique file, see Peter Nowell and David Hungerford, “A Minute Chromosome in persistent Granulocytic Leukemia,” technological know-how 132, no. 3438 (November 1960): 1497. 24. while a gene referred to as Rb: S. H. pal, R. A. Weinberg, et al. , “A Human DNA phase with homes of the Gene That Predisposes to Retinoblastoma and Osteosarcoma,” Nature 323, no. 6089 (October sixteen, 1986): 643–46 [http://www. ncbi. nlm. nih. gov/pubmed/2877398]; and J. A. DeCaprio et al. , “The fabricated from the Retinoblastoma Susceptibility Gene Has houses of a mobilephone Cycle Regulatory Element,” cellphone fifty eight, no. 6 (September 22, 1989): 1085–95. [http://www. ncbi. nlm. nih. gov/pubmed/2673542] 25. either copies has to be knocked out: this can be referred to as the two-hit speculation. See Alfred G. Knudson, “Mutation and melanoma: Statistical research of Retinoblastoma,” court cases of the nationwide Academy of Sciences sixty eight, no. four (April 1971): 820–23. [http://www. ncbi. nlm. nih. gov/pubmed/5279523] 26. eager about the timekeeping: See, for instance, DeCaprio et al. , “The manufactured from the Retinoblastoma Susceptibility Gene. ” [http://www. ncbi. nlm. nih. gov/pubmed/2673542] 27. sits on the middle of an internet: C. A. Finlay, P. W. Hinds, and A. J. Levine, “The P53 Proto-oncogene Can Act as a Suppressor of Transformation,” mobilephone fifty seven, no. 7 (June 30, 1989): 1083–93 [http://www. ncbi. nlm. nih. gov/pubmed/2525423]; and M. B. Kastan, B. Vogelstein, et al. , “Participation of P53 Protein within the mobile reaction to DNA Damage,” half 1, melanoma examine fifty one, no. 23 (December 1, 1991): 6304–11. [http://www. ncbi. nlm. nih. gov/pubmed/1933891] 28. programmed telephone demise, or apoptosis: J. F. Kerr, A. H. Wyllie, and A. R. Currie, “Apoptosis: A simple organic Phenomenon with Wide-ranging Implications in Tissue Kinetics,” British magazine of melanoma 26, no. four (August 1972): 239–57. [http://www. ncbi. nlm. nih. gov/pubmed/4561027] 29. a precept referred to as the Hayflick restrict: L. Hayflick and P. S. Moorhead, “The Serial Cultivation of Human Diploid telephone Strains,” Experimental telephone learn 25, no. three (December 1961): 585–621. [http://www. sciencedirect. com/science/article/pii/0014482761901926] 30. The count number is saved by way of telomeres: the tale of the invention is advised in Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak, “Telomeres and Telomerase: the trail from Maize, Tetrahymena and Yeast to Human melanoma and Aging,” Nature drugs 12, no. 10 (October 2006): 1133–38. [http://www. ncbi. nlm. nih. gov/pubmed/17024208] the most important papers are J. W. Szostak and E. H. Blackburn, “Cloning Yeast Telomeres on Linear Plasmid Vectors,” telephone 29, no. 1 (May 1982): 245–55 [http://www. ncbi. nlm. nih. gov/pubmed/6286143]; C. W. Greider and E. H. Blackburn, “Identification of a particular Telomere Terminal Transferase job in Tetrahymena Extracts, mobilephone 43(1985): 405–13 [http://www. ncbi. nlm. nih. gov/pubmed/3907856]; and C. W. Greider and E. H. Blackburn, “A Telomeric series within the RNA of Tetrahymena Telomerase Required for Telomere Repeat Synthesis,” Nature 337 (1989): 331–37.

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